Valvular heart disease in Parkinson's disease patients treated with dopamine agonists: A reader‐blinded monocenter echocardiography study
Identifieur interne : 002B03 ( Main/Exploration ); précédent : 002B02; suivant : 002B04Valvular heart disease in Parkinson's disease patients treated with dopamine agonists: A reader‐blinded monocenter echocardiography study
Auteurs : Susann Junghanns [Allemagne] ; Joerg T. Fuhrmann [Allemagne] ; Gregor Simonis [Allemagne] ; Christian Oelwein [Allemagne] ; Rainer Koch [Allemagne] ; Ruth H. Strasser [Allemagne] ; Heinz Reichmann [Allemagne] ; Alexander Storch [Allemagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2007-01-15.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Benzothiazoles (therapeutic use), Cardiac valvular disease, Dopamine Agonists (therapeutic use), Dopamine agonist, Double-Blind Method, Echocardiography, Echocardiography (instrumentation), Ergolines (therapeutic use), Ergot derivatives, Female, Fibrosis, Fibrosis (epidemiology), Fibrosis (pathology), Heart Valve Diseases (diagnosis), Heart Valve Diseases (epidemiology), Heart Valve Diseases (pathology), Human, Humans, Hypertrophy, Left Ventricular (diagnosis), Hypertrophy, Left Ventricular (epidemiology), Indoles (therapeutic use), Male, Middle Aged, Mitral Valve Insufficiency (diagnosis), Mitral Valve Insufficiency (epidemiology), Nervous system diseases, Parkinson Disease (drug therapy), Parkinson Disease (epidemiology), Parkinson disease, Parkinson's disease, Pergolide (therapeutic use), Severity of Illness Index, Treatment, Tricuspid Valve Insufficiency (diagnosis), Tricuspid Valve Insufficiency (epidemiology), dopamine agonists, ergot derivatives, fibrosis, valvular heart disease.
- MESH :
- chemical , therapeutic use : Benzothiazoles, Dopamine Agonists, Ergolines, Indoles, Pergolide.
- diagnosis : Heart Valve Diseases, Hypertrophy, Left Ventricular, Mitral Valve Insufficiency, Tricuspid Valve Insufficiency.
- drug therapy : Parkinson Disease.
- epidemiology : Fibrosis, Heart Valve Diseases, Hypertrophy, Left Ventricular, Mitral Valve Insufficiency, Parkinson Disease, Tricuspid Valve Insufficiency.
- instrumentation : Echocardiography.
- pathology : Fibrosis, Heart Valve Diseases.
- Double-Blind Method, Female, Humans, Male, Middle Aged, Severity of Illness Index.
Abstract
Fibrotic valvular heart disease (VHD) has been reported in association with ergot dopamine agonists (DAs), but the current database is insufficient regarding clinical relevance and comparison to data on non‐ergot DAs. We evaluated the effects of four DAs (pergolide, cabergoline, ropinirole, pramipexole) on morphology and function of heart valves in patients with Parkinson's disease (PD) to determine the frequency and clinical relevance of DA‐induced VHD. A total of 85 patients treated with ergot or non‐ergot DAs and 38 age‐matched controls were evaluated by transthoracic echocardiography. Valvular pathology was assessed by established criteria of valvular regurgitation and a VHD scoring system. Both grading systems revealed increased frequency of VHD in ergot DA patients compared to both non‐ergot DA patients and controls with 22% of ergot DA patients having moderate VHD versus 3% of non‐ergot DA patients and none of controls (P = 0.001). We did not find correlations of echocardiographic findings with duration/cumulative dose of treatment, age, or vascular risk factors. Our data suggest that ergot DAs are associated with higher prevalence of VHD compared to non‐ergot DAs and controls. Standard echocardiography seems sufficient to detect VHD in PD patients treated with DAs. © 2006 Movement Disorder Society
Url:
DOI: 10.1002/mds.21225
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 001F23
- to stream Istex, to step Curation: 001F23
- to stream Istex, to step Checkpoint: 001611
- to stream PubMed, to step Corpus: 002990
- to stream PubMed, to step Curation: 002990
- to stream PubMed, to step Checkpoint: 002485
- to stream Ncbi, to step Merge: 001949
- to stream Ncbi, to step Curation: 001949
- to stream Ncbi, to step Checkpoint: 001949
- to stream Main, to step Merge: 003A25
- to stream PascalFrancis, to step Corpus: 001802
- to stream PascalFrancis, to step Curation: 001519
- to stream PascalFrancis, to step Checkpoint: 001407
- to stream Main, to step Merge: 003F97
- to stream Main, to step Curation: 002B03
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Valvular heart disease in Parkinson's disease patients treated with dopamine agonists: A reader‐blinded monocenter echocardiography study</title><author><name sortKey="Junghanns, Susann" sort="Junghanns, Susann" uniqKey="Junghanns S" first="Susann" last="Junghanns">Susann Junghanns</name></author><author><name sortKey="Fuhrmann, Joerg T" sort="Fuhrmann, Joerg T" uniqKey="Fuhrmann J" first="Joerg T." last="Fuhrmann">Joerg T. Fuhrmann</name></author><author><name sortKey="Simonis, Gregor" sort="Simonis, Gregor" uniqKey="Simonis G" first="Gregor" last="Simonis">Gregor Simonis</name></author><author><name sortKey="Oelwein, Christian" sort="Oelwein, Christian" uniqKey="Oelwein C" first="Christian" last="Oelwein">Christian Oelwein</name></author><author><name sortKey="Koch, Rainer" sort="Koch, Rainer" uniqKey="Koch R" first="Rainer" last="Koch">Rainer Koch</name></author><author><name sortKey="Strasser, Ruth H" sort="Strasser, Ruth H" uniqKey="Strasser R" first="Ruth H." last="Strasser">Ruth H. Strasser</name></author><author><name sortKey="Reichmann, Heinz" sort="Reichmann, Heinz" uniqKey="Reichmann H" first="Heinz" last="Reichmann">Heinz Reichmann</name></author><author><name sortKey="Storch, Alexander" sort="Storch, Alexander" uniqKey="Storch A" first="Alexander" last="Storch">Alexander Storch</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:650C2C7E7BC3B71E8B4BB1E2146DDCBC71587511</idno><date when="2007" year="2007">2007</date><idno type="doi">10.1002/mds.21225</idno><idno type="url">https://api.istex.fr/document/650C2C7E7BC3B71E8B4BB1E2146DDCBC71587511/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001F23</idno><idno type="wicri:Area/Istex/Curation">001F23</idno><idno type="wicri:Area/Istex/Checkpoint">001611</idno><idno type="wicri:doubleKey">0885-3185:2007:Junghanns S:valvular:heart:disease</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:17094087</idno><idno type="wicri:Area/PubMed/Corpus">002990</idno><idno type="wicri:Area/PubMed/Curation">002990</idno><idno type="wicri:Area/PubMed/Checkpoint">002485</idno><idno type="wicri:Area/Ncbi/Merge">001949</idno><idno type="wicri:Area/Ncbi/Curation">001949</idno><idno type="wicri:Area/Ncbi/Checkpoint">001949</idno><idno type="wicri:doubleKey">0885-3185:2007:Junghanns S:valvular:heart:disease</idno><idno type="wicri:Area/Main/Merge">003A25</idno><idno type="wicri:source">INIST</idno><idno type="RBID">Pascal:07-0133250</idno><idno type="wicri:Area/PascalFrancis/Corpus">001802</idno><idno type="wicri:Area/PascalFrancis/Curation">001519</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">001407</idno><idno type="wicri:doubleKey">0885-3185:2007:Junghanns S:valvular:heart:disease</idno><idno type="wicri:Area/Main/Merge">003F97</idno><idno type="wicri:Area/Main/Curation">002B03</idno><idno type="wicri:Area/Main/Exploration">002B03</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Valvular heart disease in Parkinson's disease patients treated with dopamine agonists: A reader‐blinded monocenter echocardiography study</title><author><name sortKey="Junghanns, Susann" sort="Junghanns, Susann" uniqKey="Junghanns S" first="Susann" last="Junghanns">Susann Junghanns</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Technical University of Dresden, Dresden</wicri:regionArea><placeName><region type="land" nuts="1">Saxe (Land)</region><region type="district" nuts="2">District de Dresde</region><settlement type="city">Dresde</settlement></placeName></affiliation></author><author><name sortKey="Fuhrmann, Joerg T" sort="Fuhrmann, Joerg T" uniqKey="Fuhrmann J" first="Joerg T." last="Fuhrmann">Joerg T. Fuhrmann</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Medicine/Cardiology, Heart Center Dresden, Technical University of Dresden, Dresden</wicri:regionArea><placeName><region type="land" nuts="1">Saxe (Land)</region><region type="district" nuts="2">District de Dresde</region><settlement type="city">Dresde</settlement></placeName></affiliation></author><author><name sortKey="Simonis, Gregor" sort="Simonis, Gregor" uniqKey="Simonis G" first="Gregor" last="Simonis">Gregor Simonis</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Medicine/Cardiology, Heart Center Dresden, Technical University of Dresden, Dresden</wicri:regionArea><placeName><region type="land" nuts="1">Saxe (Land)</region><region type="district" nuts="2">District de Dresde</region><settlement type="city">Dresde</settlement></placeName></affiliation></author><author><name sortKey="Oelwein, Christian" sort="Oelwein, Christian" uniqKey="Oelwein C" first="Christian" last="Oelwein">Christian Oelwein</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Practice of Neurology, Gera</wicri:regionArea><wicri:noRegion>Gera</wicri:noRegion><wicri:noRegion>Gera</wicri:noRegion></affiliation></author><author><name sortKey="Koch, Rainer" sort="Koch, Rainer" uniqKey="Koch R" first="Rainer" last="Koch">Rainer Koch</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Biometrics and Medical Informatics, Technical University of Dresden, Dresden</wicri:regionArea><placeName><region type="land" nuts="1">Saxe (Land)</region><region type="district" nuts="2">District de Dresde</region><settlement type="city">Dresde</settlement></placeName></affiliation></author><author><name sortKey="Strasser, Ruth H" sort="Strasser, Ruth H" uniqKey="Strasser R" first="Ruth H." last="Strasser">Ruth H. Strasser</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Medicine/Cardiology, Heart Center Dresden, Technical University of Dresden, Dresden</wicri:regionArea><placeName><region type="land" nuts="1">Saxe (Land)</region><region type="district" nuts="2">District de Dresde</region><settlement type="city">Dresde</settlement></placeName></affiliation></author><author><name sortKey="Reichmann, Heinz" sort="Reichmann, Heinz" uniqKey="Reichmann H" first="Heinz" last="Reichmann">Heinz Reichmann</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Technical University of Dresden, Dresden</wicri:regionArea><placeName><region type="land" nuts="1">Saxe (Land)</region><region type="district" nuts="2">District de Dresde</region><settlement type="city">Dresde</settlement></placeName></affiliation></author><author><name sortKey="Storch, Alexander" sort="Storch, Alexander" uniqKey="Storch A" first="Alexander" last="Storch">Alexander Storch</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Technical University of Dresden, Dresden</wicri:regionArea><placeName><region type="land" nuts="1">Saxe (Land)</region><region type="district" nuts="2">District de Dresde</region><settlement type="city">Dresde</settlement></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2007-01-15">2007-01-15</date><biblScope unit="vol">22</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="234">234</biblScope><biblScope unit="page" to="237">237</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">650C2C7E7BC3B71E8B4BB1E2146DDCBC71587511</idno><idno type="DOI">10.1002/mds.21225</idno><idno type="ArticleID">MDS21225</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Benzothiazoles (therapeutic use)</term><term>Cardiac valvular disease</term><term>Dopamine Agonists (therapeutic use)</term><term>Dopamine agonist</term><term>Double-Blind Method</term><term>Echocardiography</term><term>Echocardiography (instrumentation)</term><term>Ergolines (therapeutic use)</term><term>Ergot derivatives</term><term>Female</term><term>Fibrosis</term><term>Fibrosis (epidemiology)</term><term>Fibrosis (pathology)</term><term>Heart Valve Diseases (diagnosis)</term><term>Heart Valve Diseases (epidemiology)</term><term>Heart Valve Diseases (pathology)</term><term>Human</term><term>Humans</term><term>Hypertrophy, Left Ventricular (diagnosis)</term><term>Hypertrophy, Left Ventricular (epidemiology)</term><term>Indoles (therapeutic use)</term><term>Male</term><term>Middle Aged</term><term>Mitral Valve Insufficiency (diagnosis)</term><term>Mitral Valve Insufficiency (epidemiology)</term><term>Nervous system diseases</term><term>Parkinson Disease (drug therapy)</term><term>Parkinson Disease (epidemiology)</term><term>Parkinson disease</term><term>Parkinson's disease</term><term>Pergolide (therapeutic use)</term><term>Severity of Illness Index</term><term>Treatment</term><term>Tricuspid Valve Insufficiency (diagnosis)</term><term>Tricuspid Valve Insufficiency (epidemiology)</term><term>dopamine agonists</term><term>ergot derivatives</term><term>fibrosis</term><term>valvular heart disease</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Benzothiazoles</term><term>Dopamine Agonists</term><term>Ergolines</term><term>Indoles</term><term>Pergolide</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Heart Valve Diseases</term><term>Hypertrophy, Left Ventricular</term><term>Mitral Valve Insufficiency</term><term>Tricuspid Valve Insufficiency</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Fibrosis</term><term>Heart Valve Diseases</term><term>Hypertrophy, Left Ventricular</term><term>Mitral Valve Insufficiency</term><term>Parkinson Disease</term><term>Tricuspid Valve Insufficiency</term></keywords><keywords scheme="MESH" qualifier="instrumentation" xml:lang="en"><term>Echocardiography</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Fibrosis</term><term>Heart Valve Diseases</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Double-Blind Method</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Severity of Illness Index</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Cardiopathie valvulaire</term><term>Echocardiographie</term><term>Ergot dérivé</term><term>Fibrose</term><term>Homme</term><term>Parkinson maladie</term><term>Stimulant dopaminergique</term><term>Système nerveux pathologie</term><term>Traitement</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Fibrotic valvular heart disease (VHD) has been reported in association with ergot dopamine agonists (DAs), but the current database is insufficient regarding clinical relevance and comparison to data on non‐ergot DAs. We evaluated the effects of four DAs (pergolide, cabergoline, ropinirole, pramipexole) on morphology and function of heart valves in patients with Parkinson's disease (PD) to determine the frequency and clinical relevance of DA‐induced VHD. A total of 85 patients treated with ergot or non‐ergot DAs and 38 age‐matched controls were evaluated by transthoracic echocardiography. Valvular pathology was assessed by established criteria of valvular regurgitation and a VHD scoring system. Both grading systems revealed increased frequency of VHD in ergot DA patients compared to both non‐ergot DA patients and controls with 22% of ergot DA patients having moderate VHD versus 3% of non‐ergot DA patients and none of controls (P = 0.001). We did not find correlations of echocardiographic findings with duration/cumulative dose of treatment, age, or vascular risk factors. Our data suggest that ergot DAs are associated with higher prevalence of VHD compared to non‐ergot DAs and controls. Standard echocardiography seems sufficient to detect VHD in PD patients treated with DAs. © 2006 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>District de Dresde</li><li>Saxe (Land)</li></region><settlement><li>Dresde</li></settlement></list><tree><country name="Allemagne"><region name="Saxe (Land)"><name sortKey="Junghanns, Susann" sort="Junghanns, Susann" uniqKey="Junghanns S" first="Susann" last="Junghanns">Susann Junghanns</name></region><name sortKey="Fuhrmann, Joerg T" sort="Fuhrmann, Joerg T" uniqKey="Fuhrmann J" first="Joerg T." last="Fuhrmann">Joerg T. Fuhrmann</name><name sortKey="Koch, Rainer" sort="Koch, Rainer" uniqKey="Koch R" first="Rainer" last="Koch">Rainer Koch</name><name sortKey="Oelwein, Christian" sort="Oelwein, Christian" uniqKey="Oelwein C" first="Christian" last="Oelwein">Christian Oelwein</name><name sortKey="Reichmann, Heinz" sort="Reichmann, Heinz" uniqKey="Reichmann H" first="Heinz" last="Reichmann">Heinz Reichmann</name><name sortKey="Simonis, Gregor" sort="Simonis, Gregor" uniqKey="Simonis G" first="Gregor" last="Simonis">Gregor Simonis</name><name sortKey="Storch, Alexander" sort="Storch, Alexander" uniqKey="Storch A" first="Alexander" last="Storch">Alexander Storch</name><name sortKey="Strasser, Ruth H" sort="Strasser, Ruth H" uniqKey="Strasser R" first="Ruth H." last="Strasser">Ruth H. Strasser</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002B03 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002B03 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= MovDisordV3
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:650C2C7E7BC3B71E8B4BB1E2146DDCBC71587511
|texte= Valvular heart disease in Parkinson's disease patients treated with dopamine agonists: A reader‐blinded monocenter echocardiography study
}}
| This area was generated with Dilib version V0.6.23. |  |